Manipulation of stem cells and application in medicine pdf
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- Stem cell drugs: the next generation of pharmaceutical products
- Regulatory Issues in the Therapeutic Use of Stem Cells
Regenerative Medicine and Tissue Engineering.
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Metrics details. Stem cells are a relevant source of information about cellular differentiation, molecular processes and tissue homeostasis, but also one of the most putative biological tools to treat degenerative diseases. This review focuses on human stem cells clinical and experimental applications. Our aim is to take a correct view of the available stem cell subtypes and their rational use in the medical area, with a specific focus on their therapeutic benefits and side effects. We have reviewed the main clinical trials dividing them basing on their clinical applications, and taking into account the ethical issue associated with the stem cell therapy. All the relevant clinical trials have been included.
Search for the other articles from the author in: Google Scholar PubMed. Total Citations. Submitted: Oct 29, Published: Oct 29, Vol 3 No 10 DOI: Copyrights: Phuc Van Pham, License: This work is licensed under a Creative Commons Attribution 4. Stem cells represent a new treatment option in medicine and pharmacy.
Regenerative medicine, the most recent and emerging branch of medical science, deals with functional restoration of tissues or organs for the patient suffering from severe injuries or chronic disease. The spectacular progress in the field of stem cell research has laid the foundation for cell based therapies of disease which cannot be cured by conventional medicines. The indefinite self-renewal and potential to differentiate into other types of cells represent stem cells as frontiers of regenerative medicine. The transdifferentiating potential of stem cells varies with source and according to that regenerative applications also change. Advancements in gene editing and tissue engineering technology have endorsed the ex vivo remodelling of stem cells grown into 3D organoids and tissue structures for personalized applications. Additionally, this review also discusses stem cells regenerative application in wildlife conservation.
Stem cell drugs: the next generation of pharmaceutical products
Most cells in the body are differentiated cells. These cells can only serve a specific purpose in a particular organ. For example, red blood cells are specifically designed to carry oxygen through the blood. All humans start out as only one cell. This cell is called a zygote, or a fertilized egg.
Review Series Free access Phone: ; Fax: ; E-mail: insoo. Find articles by Hyun, I. Published January 4, - More info. Discussion of the bioethics of human stem cell research has transitioned from controversies over the source of human embryonic stem cells to concerns about the ethical use of stem cells in basic and clinical research. Key areas in this evolving ethical discourse include the derivation and use of other human embryonic stem cell—like stem cells that have the capacity to differentiate into all types of human tissue and the use of all types of stem cells in clinical research. Each of these issues is discussed as I summarize the past, present, and future bioethical issues in stem cell research.
The current stem cell regenerative medicine approaches are founded onto tissue engineering technologies that combine the principles of cell transplantation.
Regulatory Issues in the Therapeutic Use of Stem Cells
Metrics details. There is much to be investigated about the specific characteristics of stem cells and about the efficacy and safety of the new drugs based on this type of cells, both embryonic as adult stem cells, for several therapeutic indications cardiovascular and ischemic diseases, diabetes, hematopoietic diseases, liver diseases. Along with recent progress in transference of nuclei from human somatic cells, as well as iPSC technology, has allowed availability of lineages of all three germ layers genetically identical to those of the donor patient, which permits safe transplantation of organ-tissue-specific adult stem cells with no immune rejection. The main objective is the need for expansion of stem cell characteristics to maximize stem cell efficacy i. Other considerations to take into account in cell therapy will be the suitability of infrastructure and technical staff, biomaterials, production costs, biobanks, biosecurity, and the biotechnological industry.
Not a MyNAP member yet? Register for a free account to start saving and receiving special member only perks. S tem cell research offers unprecedented opportunities for developing new medical therapies for debilitating diseases and a new way to explore fundamental questions of biology. Stem cells are unspecialized cells that can self-renew indefinitely and also differentiate into more mature cells with specialized functions. Research on human embryonic stem cells, however, is controversial, given the diverse views held in our society about the moral and legal status of the early embryo.